Center for Modeling Integrated Metabolic Systems

Mission

The Center for Modeling Integrated Metabolic Systems (MIMS) combines mathematical modeling, computer simulation, and in vivo experimentation to quantify relationships between cellular metabolism and physiological responses of tissue-organ systems and the whole body. This involves many inter-disciplinary research teams from Case Western Reserve University, Cleveland State University,Case Medical Center and Cleveland Clinic Foundation of Cleveland. Primary emphasis is given to cellular metabolism in four major tissue-organ systems: skeletal muscle, brain, heart, and liver. The tissue-organ systems are related through blood circulation by an integrative whole-body model. Physiologically based models incorporate cellular metabolic reactions and transport processes of a large number of chemical species. Such models allow quantitative evaluation of metabolic pathways and regulatory mechanisms under normal and abnormal conditions as well as disease states. Model simulations provide the basis for analyzing of experimental responses to changes including blood flow, oxygen, exercise, and diet. Experimentally validated models can be used to predict the effects of altering metabolic processes with pharmacological agents.